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Semaglutide is often optimized to maximize weight loss, yet it remains unclear whether long-term cardiovascular benefit is more closely associated with achieved weight reduction or therapeutic exposure

GLP-1 drugs are effective weight loss tools, but exactly how they work is still mysterious.

Future research should account for non-diabetic patients, assess lifestyle factors, and exclude other psychotropic medications that may affect weight.

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Five randomized trials including 920 patients from the USA, Mexico, Brazil, the Netherlands, and Egypt were included