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Patent filings have concentrated on sequence optimization, receptor balance, and dosing regimens [5, 6], while scientific reviews increasingly position these compounds as the next frontier beyond single-target GLP-1 therapy [1, 2]
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Acknowledgements We thank Christopher Rhodes, PhD, for his expert review of the manuscript and helpful discussions
doi: 10.1016/S0140-6736(19)31150-X 42 TuttleKRLakshmananMCRaynerBBuschRSZimmermannAGWoodwardDBet al
