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Associations Between Weight Loss and Gastrointestinal Adverse Events on GLP-1RA Therapy While gastrointestinal adverse events that occur with GLP-1RAs are mainly mild-to-moderate and transient, occurring particularly during dose escalation, there may be concerns that GLP-1RA-mediated weight loss could be due to these effects

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However, anyone with cardiovascular history, severe gastrointestinal concerns, or rapid dose escalation needs should prioritize frequent provider oversighta factor favoring structured clinical programs

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