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Extended titration, where you stay at a lower dose for longer before increasing, is the evidence-based approach to managing GI side effects and may solve your problem without any experimental modifications

doi: 10.1016/j.biopsych.2015.09.011

When to use 10mg versus 5mg vials A 5mg vial makes more sense during early dose escalation (0.25mg to 0.5mg weekly) because you will use less total peptide over the 28-day reconstitution window