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Description

GLP-1 activation suppresses appetite and slows gastric emptying, while GIP signaling is thought to enhance energy expenditure, improve insulin sensitivity in adipose tissue, and reduce gastrointestinal side effects through central mechanisms

In June 2023, an international, multi-society guided Delphi process established the definition of metabolic dysfunction-associated steatotic liver disease (MASLD), which is defined as the presence of high triglyceride (TG) storage inside the hepatocytes in the presence of at least one cardiometabolic risk factor, trying to unveil the nuances of a heterogenous and complex disorder [6, 7]

Ideally, these discussions occur before therapy begins

Engaging with a healthcare provider who considers individual challengessuch as cultural dietary habits, work-related fatigue, or family responsibilitiesmay support more sustainable weight loss outcomes