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2.2 Clinical studies Curiously, an epidemiologic, large-scale, population-based study on 6,800,000 individuals from the database of the Korean National Health Insurance Service observed that being underweight may be a risk factor for the development of PD

Current status: TRIUMPH-4 results available: December 2025 readout showing 28.7% weight loss at 68 weeks (Giblin et al., PMID 41090431) Additional TRIUMPH trials: Expected to report results through 2026, including TRIUMPH-Outcomes (cardiovascular endpoints, NCT06383390, completion Feb 2029) NDA submission timing: Eli Lilly must compile the full trial package before submitting

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Overall, the PIONEER and SUSTAIN exposure-response populations were similar, with the main difference being the inclusion of a dedicated study of patients with moderate renal impairment and a trial with concomitant insulin treatment in the PIONEER program

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