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These neurotransmitters play key roles in mood regulation and other brain functions

Since an increase of [Ca 2+ ] i triggers GLP-1 release from intestinal L-cells 10 , and since L-cells express TRPA1 channels 9 , these findings indicated that JWU-A021 might serve as the prototype of a new class of small molecule GLP-1 secretagogues with TRPA1 channel activating properties

[DOI] [PubMed] [Google Scholar] 47.Wharton S, Calanna S, Davies M, Dicker D, Goldman B, Lingvay I, et al

Semaglutide research is expanding into addiction biology , characterising attenuation of reward responses to alcohol, nicotine, and other substances through nucleus accumbens GLP-1R modulation and neurodegeneration , documenting neuroprotective and anti-neuroinflammatory effects in Parkinsons and Alzheimers disease models

Cardiovascular Benefits Beyond its effects on weight and glycemic control, it has shown potential cardiovascular benefits in clinical trials