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Other medications, such as Ozempic (semaglutide) and Mounjaro (tirzepatide), are approved for diabetes but are often used off-label to help patients lose weight. A small 2024 study showed promising results: When a small group of postmenopausal women were treated with semaglutide for one year, those who also received HRT showed approximately 30% more weight loss than those who didnt receive HRT in conjunction with the drug

The GLP-1 Access Gap: Mapping Who Can Actually Afford Americas Miracle Weight-Loss Drugs Published 2/4/2026 Author: Andrew Reed, Assoc

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A 2025 retrospective cohort of 125,474 adults initiating GLP-1 receptor agonists found that 46.5% of patients with type 2 diabetes and 64.8% without type 2 diabetes discontinued therapy within one year