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Survival outcomes were comparable between the two study arms, with no significant difference reported for median survival
Effect of glucagon-like peptide-1 receptor agonists on lipid profiles among type 2 diabetes: A systematic review and network meta-analysis

To overcome these resistance mechanisms, several sensitization strategies have been developed

Patients should have realistic expectations and be prepared to engage with lifestyle interventions as the foundation of obesity management

Retatrutide is promising because of its triple-agonist mechanism and strong weight-loss data, but current public evidence is not enough to make a firm superiority claim specifically for muscle preservation compared with semaglutide or tirzepatide
