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Creatine also draws water into the muscle, which can mean a small, harmless scale increase early on , worth knowing so you do not misread it as fat gain while you are tracking weight loss

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doi: 10.1210/en.2008-0828 73 KerrBDFlattPRGaultVA
Potential immune reactions include: Injection site reactions beyond normal (excessive redness, swelling, itching) Systemic allergic responses (rash, hives, difficulty breathing in extreme cases) Development of anti-drug antibodies that could reduce the effectiveness of future semaglutide doses This last point is particularly concerning for long-term users

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