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The drugs are also effective in promoting weight loss if taken according to their treatment plan, which means patients should take the drugs continuously for at least 12 weeks

Deletion of GIP receptor has been found to counteract high-fat diet induced weight gain in mice, suggesting a causal role of GIP in development of obesity [36]

[DOI] [PubMed] [Google Scholar] 54.Vilsbll T

A phase 3, multi-center trial called the Exenatide PD3 Study is coming to an end in the United Kingdom, with initial results expected in summer 2024

Thus, ARRB2 plays distinct roles in regulating GLP-1R and GIPR signaling, and this study highlights (1) its role in the physiological context and the possible functional consequences of its decreased expression in pathological situations such as diabetes and (2) the importance of assessing the signaling pathways engaged by the agonists (biased/dual) for therapeutic purposes..