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Glucose spills into urine osmotic diuresis dehydration, electrolyte loss Clinical Features: Symptoms: Polyuria, polydipsia Nausea, vomiting Abdominal pain Fruity-smelling breath (due to ketones) Shortness of breath Confusion or drowsiness Signs: Dehydration (dry mucous membranes, sunken eyes) Kussmaul breathing (deep, labored breathing) Tachycardia, hypotension Altered mental status coma (in severe cases) Diagnostic Criteria (Blood tests): Parameter DKA Diagnostic Range Blood glucose

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The data suggest a crosstalk between AT and pancreas to fine-tune energy metabolic system or may minimize the metabolic damage during diabetes

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