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P38 Mitogen-Activated Protein Kinase Signaling Mediates Exenatide-Stimulated Microglial -Endorphin Expression

2017;5:e13102

The FDA label carries a boxed warning regarding thyroid medullary carcinoma risk, contraindicating use in patients with personal or family history of this condition or Multiple Endocrine Neoplasia syndrome type 2

These medications work through multiple complementary mechanisms: they enhance glucose-dependent insulin secretion from pancreatic beta cells, suppress inappropriate glucagon release from alpha cells, slow gastric emptying to reduce postprandial glucose excursions, and act on central nervous system pathways to promote satiety and reduce appetite

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