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By Sabina Paglialunga, PhD & Aernout van Haarst, PhD Senior Directors Scientific Affairs Glucagon-Like Peptide-1 (GLP-1) receptor agonists first came to the market in 2005 as a type 2 diabetes mellitus treatment, and they have been making headlines again for their weight reduction effects

1 Tirzepatide, which acts on both the GIP and GLP-1 systems, also substantially cuts appetite and food intake

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Among these, obesity (defined by the WHO as a body mass index (BMI) 30 kg/m 2 ) [6], is characterized by low-grade inflammation driven by adipokine secretion from adipose tissue