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They are prepared by licensed compounding pharmacies under pharmacist supervision and state pharmacy board oversight

OFA also submitted a comment to the FDA that argues the semaglutide shortage remains ongoing: OFA conservatively estimates that roughly 80 million prescriptions for semaglutide were fulfilled with compounded semaglutide in the last 12 months, inclusive of 503A pharmacy compounders and 503B outsourcing facilities

This places them solidly in the middle-to-upper tier of compounded tirzepatide providers

Other GLP-1s like exenatide (Byetta, now discontinued), liraglutide (Victoza), and dulaglutide (Trulicity) reduced plasma levels of oral contraceptives by up to 45 percent and delayed absorption by up to 3.5 hours, though not enough to cause the birth control to fail

Look out for non-scale victories like: Feeling more energetic throughout the day Enjoying better, more restful sleep Experiencing sharper mental focus Noticing clothes fitting more comfortably Easing of joint pain or physical discomfort Seeing positive changes in your skin You can also celebrate fitness achievements, like walking longer distances, lifting heavier weights, or simply feeling stronger in daily activities