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Genetic Predispositions in GLP-1 Metabolic Pathways Emerging evidence suggests that genetic variants in GLP-1 receptor pathways, appetite signaling genes, and metabolic regulators may influence how quickly individuals experience and tolerate GLP-1 side effects

That is a consistent pattern of failure to demonstrate the primary endpoint: significant fat reduction in humans

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NICE guidance (NG7 and TA875) emphasises the importance of dietary support alongside pharmacological interventions for obesity management, and healthcare professionals typically provide patients with practical eating strategies when prescribing GLP-1 receptor agonists