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The risk is lower when combined with metformin alone

Force UPST

Importantly, ongoing studies are now deepening the understanding of the effects of GLP-1RAs in different HF cohorts (e.g., patients with HFpEF and those with advanced HF) [144,145,146]

Glucagon-like peptide 1 (GLP-1), for example, is a peptide secreted by the gastrointestinal tract in response to food intake, which leads to the secretion of insulin and inhibition of glucagon release, both of which facilitate glucose homeostasis

Receptor-mediated activation of gastric vagal afferents by glucagonlike peptide1 in the rat
