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The researchers found that semaglutide improved the Kansas City Cardiomyopathy Questionnaire Clinical Summary Score in all diuretic subgroups, but the magnitude of improvement was greater in patients receiving loop diuretics versus those not on loop diuretics (adjusted mean difference of 9.3 versus 4.7 points, respectively)
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It remains to be determined whether similar neural mechanisms mediate the behavioral effects of GLP-1 receptor agonists in drug-dependent animals that have been stably self-administering cocaine for a prolonged period of time
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