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The mouse models included lean mice (C57BL/6J and NSY.B6- a / a ), obese diabetic mice (NSY.B6- Ay / a ), proglucagon-deficient mice ( Gcg -/-), glucose-dependent insulinotropic polypeptide (GIP) receptor-deficient mice ( Gipr -/-), and ATP-sensitive potassium channel (KATP channel)-deficient mice ( Kcnj11 -/-)

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High-profile celebrities have publicly discussed using GLP-1 receptor agonists for weight management, sparking global interest in semaglutide and tirzepatide

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of the $118M in the cost increase request, more than $76 million would be coming from federal dollars.
