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Dosage used for weight loss management is a lot smaller compared to treating Diabetes

The Era of Small-Molecule GLP-1 Drugs Is Emerging The approval of Orforglipron represents more than the launch of a new drugit reflects a major shift in oral GLP-1 drug development trends toward small-molecule innovation
Patients were to continue their current treatment on metformin at a stable, pre-trial dose level and dosing frequency
For anyone with cardiovascular risk factors, and the majority of people with obesity have at least one, this distinction between a medication that raises cardiovascular stress and one that reduces it is arguably more important than the weight loss difference itself

Differential effect of global signal regression between awake and anesthetized conditions in mice