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AI-Designed Peptides Outperform GLP-1 in Lab June 3, 2025 67% of AI-designed peptides outperformed GLP-1 in binding assays vs
Concomitant medications At randomisation, on average, individuals in both arms were treated with one glucose-lowering agent
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Importance of Aggregate Analysis Aggregates may: Alter pharmacokinetic behavior Increase immunogenicity risk Reduce therapeutic potency Impact formulation stability Analytical Challenges Aggregate characterization often requires: Orthogonal analytical methods SEC coupled with MS Native mass spectrometry Stability-indicating analytical workflows Using multiple complementary techniques improves confidence in impurity detection and biosimilar comparability
