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GLP-1 receptor agonistsincluding semaglutide (Ozempic, Wegovy), dulaglutide (Trulicity), and liraglutide (Victoza, Saxenda)are temperature-sensitive biologic medications used for type 2 diabetes and weight management

While the Phase 2 trial did not specifically stratify outcomes by baseline eGFR, GLP-1 receptor agonists as a class have demonstrated renoprotective effects in at-risk populations

Therefore, the frequency of AEs seen in the current multiple-dose trial may not be reflective of the frequency of AEs for oral semaglutide at the doses expected to be used in the clinical setting and following the most recent recommendations on dosing conditions

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employed a diet-induced NASH mouse model to compare the efficacy of cotadutide (a dual GLP-1/GCG agonist) against liraglutide (selective GLP-1 receptor agonist) and pair-fed controls