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That came out of animal model studies, where they gave large amounts of these drugs, and the animal model would get what's called C cell hyperplasia

In clinical studies treatment with liraglutide was associated with an increase in HR (mean difference 7 bpm) and more serious cardiac adverse events (3% vs 10% for placebo and liraglutide, respectively) in chronic heart failure patients with and without type 2 diabetes (135)

Despite this reassuring human data, UK product information contains warnings and precautions regarding thyroid C-cell tumours based on rodent data

PMID: 41506148

Xue Zhao, Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, 130021, Peoples Republic of China, Tel +86 15843081103