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Gallbladder disease: Cholelithiasis (gallstones) and cholecystitis have been reported with GLP-1-based therapies, likely related to rapid weight loss
Read the full breakdown 4 Last updated: June 2, 2026 Quick Answer: The FDAs GLP-1 drug shortage list has been one of the most consequential regulatory events in recent pharmaceutical history

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Metabolic reprogramming through histone lactylation in microglia and macrophages recruits CD8(+) T lymphocytes and aggravates spinal cord injury
Eli Lilly also weighed in on the matter, saying in a statement to Reuters: "No one should be mass-compounding or selling knock-off GLP-1 products regardless of how theyre administered." The pair have tried to halt the burgeoning compounded GLP-1 industry in its tracks, but have had mixed success given the breadth of manufacturers that have cropped up
