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10.1016/S0167-0115(01)00237-3 31 DhillonS

Taken together, evidence from the STEP, SURMOUNT, and S-LiTE trials strongly supports the lifestyle interventions, particularly dietary modification and structured exercise, being not only compatible with but also additive to the effects of GLP-1 therapies

Animal models have shown that GLP1 and its analogues, such as exendin4, can induce anxietylike behaviours in rodents

No randomized controlled trials have specifically evaluated GLP-1 receptor agonists as primary therapy for Crohn's disease, though a search of ClinicalTrials.gov reveals a few early-phase studies are being planned or conducted
