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Moreover, secretion of TNF- and IL1- into the conditioned media was significantly downregulated by exendin-4 when compared to LPS-treated cells

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The two fusion proteins were designed with either an intact C-terminal end (GLP-1 WT and GLP-1 QMP) or a truncated end lacking L585 (GLP-1 LX and GLP-1 QMP/LX) (Fig