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Description
Abbreviations CNRC: Childrens Nutrition Research Center FFM: Fat-free mass GIP: Gastric inhibitory polypeptide GLP-1: Glucagon-like peptide-1 GPR: Glucose production rate HISI: Hepatic insulin sensitivity index IGI: Insulinogenic index iGLP-1: Intact GLP-1 MIGHTY: Metformin Influences Gut Hormones in Youth NGT: Normal glucose tolerance NIH: National Institutes of Health PYY: Peptide YY R a : Rate of appearance WBISI: Whole-body insulin sensitivity index References Zeitler P, Hirst K, Pyle L et al (2012) A clinical trial to maintain glycemic control in youth with type 2 diabetes

the ESSENCE program supports, but has not yet completed, that regulatory path

If you keep getting reactions in one area, switch to a different approved site for a few weeks

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Some prescribers individualize dosing intervals based on patient response
