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However, in isolated mouse hearts perfused with the sAC inhibitor KH7, we observed loss of cardioprotection with GLP-1(2836), but not GLP-1, as measured by LVDP at the end of the reperfusion (25.2 1.7 mmHg, n = 3, vs

GIP Similar to the other two gut-derived hormones (GLP-1 and GLP-2), GIP influences bone remodeling as part of the entero-endocrine-osseous axis

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However, compliant weight loss drugs are extremely scarce in the face of strong demand for weight loss

Taken together, these efficacy and safety observations suggest that, for older patients without CV disease with T2DM who are not at A1C target despite metformin monotherapy, it is reasonable to preferentially recommend a DPP-4 inhibitor rather than an SGLT2 inhibitor as add-on therapy