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Description
In T2DM, variations in IR, -cell function, and tissue-specific GLP-1R expression (pancreas, liver, adipose) create diverse metabolic niches that influence the biodistribution and pharmacodynamics of nanocarriers [514516]
Different programs bias toward GIPR potency (metabolic tolerability), GCGR potency (thermogenesis, fat oxidation, hepatic effects), or GLP-1R potency (appetite)
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Referencias Emma Simonsen MD , Lars Christian Lund PhD , Martin Thomsen Ernst MSc , Vidar Hjellvik PhD , Laszlo Hegeds DMSc , Steffen Hamann PhD , ystein Kalsnes Jrstad PhD , et al
95% CI, 0.11-0.99)
