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Mechanisms identified include: increased cardiac utilization of ketones increased autophagy (recycling of intracellular components)l decreased inflammation & oxidative stress improved mitochondrial function decreased intracellular Ca & Na overload decreased fibrosis improved myocardial diastolic function decrease myocardial hypertrophy Indications: Type 2 diabetes Adjunct therapy in patients not meeting their glycemic goal with other agents (e.g

This reduction in stress can lead to improved sleep quality, allowing for deeper and more restorative rest

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Fourth, ensure adequate caloric intakesevere restriction worsens stress and deficiency

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