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Current evidence supports a broad range of TTM from 33C to 36C and should be maintained for 24 hours

This suggests that repeated intake of grapefruit juice reduces the efficacy and bioavailability of acetaminophen/paracetamol in comparison with a single dose of grapefruit juice, which conversely increases the efficacy and bioavailability of acetaminophen/paracetamol

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Many practitioners prefer to split that into two separate injections of 75 units each, administered at different sites