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GLP 1 receptor agonists addressed multiple aspects of glucose homeostasis by enhancing glucose dependent insulin secretion, suppressing glucagon release, delaying gastric emptying, and promoting satiety
Progression to kidney replacement therapy (KRT) occurred in 3.7% of patients receiving GLP-1 receptor agonists

In APP/PS1 and 3xTg-AD mice, treatment with semaglutide consistently resulted in improved performance in cognitive tasks, such as the Morris water maze, indicating enhanced spatial learning and memory

The Mechanisms of Semaglutide Therapy in Heart Failure Patients trial will assess the impact of semaglutide on biomarkers, echocardiographic parameters, and functional outcomes in patients with HF [63]
