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Semaglutide will face loss of exclusivity in multiple countries in 2026, of which Canada, India and China are the biggest markets

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Pathological mechanisms disrupt islet organization, hindering cell-to-cell communication, impairing insulin and glucagon release, and exacerbating hyperglycemia [15] Beta cell failure and insulin secretory dysfunction are fundamental in type 2 diabetes, arising from synthesis or secretion process errors

Clinical data shows that advancing from a lower maintenance dose to 15 mg tirzepatide typically produces 5-15 additional pounds of weight loss over three to six months, though individual results vary