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doi: 10.1111/dom.2016.18.issue-3 28 LiZYZhangNWenSZhangJSunXLFanXMet al

Even more compelling was the statistically significant increase in lean tissue when creatine was only consumed on training days rather than every day of the week

In select cases, temporary dose reduction or treatment interruption may be necessary while investigating symptoms, though this decision should be made collaboratively between patient and provider, weighing the benefits of continued therapy against symptom burden

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