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Should I Consider Metformin Therapy for Weight Loss in Patients With Obesity But Without Diabetes

Therefore, endogenous GIP seems to retain a role in postprandial glucose regulation following gastric sleeve but when the first part of the small intestine is bypassed (Roux-en-Y gastric bypass) endogenous GIP does not contribute to the postprandial glucose regulation (79)

doi: 10.1210/en.2007-1137 29 ShiraishiDFujiwaraYKomoharaYMizutaHTakeyaM

Participants taking the highest maintenance dose experienced weight reductions comparable to some injectable GLP-1 agents, though the timeline to reach therapeutic doses extended over several months
BMC Pharmacol Toxicol
