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Other genetic loci: Polymorphisms in genes such as CNR1, CTRB1/2 andTCF7L2, have shown associations with GLP-1RA response, particularly liraglutide, affecting glycemic control and metabolic parameters [14,133,135]

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However, important caveats exist: anyone with a personal or family history of medullary thyroid cancer or MEN2 syndrome (multiple endocrine neoplasia type 2) should not use semaglutide, as animal studies showed dose-dependent C-cell thyroid tumors

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Tumor antigens primarily fall into three categories: tumor-associated antigens (TAAs) (overexpressed in tumor cells, low expression in normal tissue), cancer/testis antigens (CTAs) (expressed in tumors and testes), and neoantigens such as tumor-specific antigens (TSAs)