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Retatrutide appears to: Target deep abdominal fat Reduce waist circumference more significantly Improve metabolic syndrome components Safety and Tolerability Side Effects: Similar to GLP-1 Agonists Nausea Vomiting Diarrhea or constipation Fatigue in early weeks Mitigation strategy: Start at low doses and titrate slowly Consider antiemetics in sensitive patients While retatrutides triple action raises theoretical concerns, early data show comparable tolerability to tirzepatide , with no increase in severe adverse events