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The mechanism isn't fully understood, but researchers believe the rapid changes in blood glucose levels and gastrointestinal hormone release play significant roles in this early side effect
One primary mechanism is slowing the emptying of the stomach, resulting in a sense of fullness over a longer period of time
Beyond the SURPASS program, the SURMOUNT trial series represents a major investigation of the efficacy of tirzepatide in obese or overweight individuals, with a focus on weight loss and diabetes risk mitigation
[DOI] [PubMed] [Google Scholar] Holst JJ, Albrechtsen NJW, Rosenkilde MM, Deacon CF
