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This is most prevalent and most pronounced in Cushings disease and acromegaly but also observed in prolactinomas, GH-deficiency, hypogonadism and hypothyroidism ( Cushings Disease Interactions between insulin and cortisol are manifold ( Figure 1 )

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However, in human mesenchymal stem cells, GLP-1 inhibited early adipocyte differentiation and instead promoted proliferation of undifferentiated mesenchymal stem cells [77]

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