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Among the numerous major discoveries made in this regard was the finding that the hyperglycemic effect of glucagon resides in its ability to act in the liver to stimulate glycogenolysis and gluconeogenesis [[6], [7], [8], [9], [10], [11], [12]] despite its seemingly paradoxical ability to stimulate insulin secretion in humans reported by Ellis Samols in 1965 [13]

And then what I typically do after prescribing is that I will measure estradiol levels usually a couple months later

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