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In recent years, GIP/GLP-1 receptor dual agonists and GIP/GLP-1/glucagon receptor triple agonists, which co-stimulate multiple hormone receptors including GIPR, continue to be reported to exert remarkable anti-obesity and hypoglycaemic effects when compared to agonists of the GLP-1R alone, and are now being applied in clinical practice

Krisai P, Aeschbacher S, Schoen T, et al

Their use is individualised and aimed at helping patients enter pregnancy in the best possible health. Women with PCOS often spend years moving between diet plans, exercise programmes, metformin prescriptions, and fertility consultations

This combination addresses both metabolic challenges and reproductive issues, offering a valuable option for managing PCOS-related obesity and infertility

The first reported GLP-1/GIP co-agonists, which had prolonged half-lives due to the use of fatty acylation or PEGylation, yielded synergistic effects, lowering body weight in obese rodents relative to the individual mono-agonist comparators [465] and having a greater insulinotropic effect in non-human primates