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Description
The FLOW trial was the first clinical trial that evaluated the effects of a GLP-1 medicine, semaglutide, on a composite outcome of progression of CKD and cardiovascular death, in people with T2D

A recent study investigated the effects of GLP-1R agonists in a multi-hit mouse model in which the combination of a high-fat diet and angiotensin II-induced a cardiometabolic HFpEF phenotype that resembles the human HFpEF phenotype to a large extent characterized by obesity, impaired glucose handling, and metabolic dysregulation accompanied by inflammation

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Sidney S, Go AS, Jaffe MG, Solomon MD, Ambrosy AP, Rana JS

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