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77 Due to its procedural simplicity, significant weight loss efficacy, and minimal impact on intestinal absorption, VSG has demonstrated an upward trend in clinical application in recent years, emerging as the most prevalent bariatric surgical procedure

Patients planning pregnancy GLP-1 medications must be discontinued before conception

-Cell GLP-1 in normal glucose regulation The accepted dogma of GLP-1 secreted from the intestine and acting on the pancreas in an endocrine manner is difficult to reconcile given the observations that GLP-1 is rapidly degraded by dipeptidylpeptidase 4 (DPP4) and very little, in fact, only approximately 10% of intestinally secreted GLP-1 reaches the circulation (39, 82, 93)

Injection site reactions include redness, itching, or mild swelling at the injection site

Researchers believe that semaglutide may help reduce inflammation, improve blood flow, and reduce oxidative stress in the kidneys