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Effect of 3 years of treatment with exenatide on postprandial glucagon levels
Moreover, GLP-1RA and DPP-4 inhibitors are approved for the treatment of T2DM and exhibit potential pleiotropic effects on the heart and kidneys, which may be independent of or dependent on the hypoglycemic effects
Consequently, it is essential to prioritize shared decision-making and individualized risk-benefit assessments for prescribing GLP-1 RAs, while avoiding misuse with off-label indications
Saxena AR, Frias JP, Brown LS, et al
Activation of the GLP-1 receptor by a non-peptidic agonist
