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Additionally, evidence indicates that GLP-1 enhances endoplasmic reticulum (ER)-mitochondria interactions, leading to increased mitochondrial activity [38]

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Other long-term considerations include gastrointestinal adaptation (most patients find side effects diminish significantly after the first 3-6 months), nutritional deficiencies that can develop with prolonged reduced caloric intake, and the psychological adjustment of maintaining a dramatically different body weight and relationship with food

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Modulation of sweet taste sensitivities by endogenous leptin and endocannabinoids in mice