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First, adequate protein preserves lean muscle mass during weight loss

This multimodal design may allow for reduced GLP-1RA dosing, mitigating adverse effects while maintaining or even amplifying anti-craving efficacy

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Antithetical activation of both GIP and GLP-1 receptors has offered a promising approach for the treatment of metabolic conditions due to their combined effects in enhancing insulin secretion, reducing energy consumption, and improving insulin sensitivity both directly and indirectly compared to GLP-1 receptor mono-agonism [45, 57]