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For patients with hypertension considering GLP-1 therapy, understanding your unique cardiovascular risk profile and genetic predispositions in metabolic pathways may help support a more informed discussion with your provider

Here is a clear framework built from what we know about both mechanisms and practical clinical experience

Not to be outdone, Eli Lilly, the manufacturer of the type 2 diabetes medication Mounjaro (which mimics both GLP-1 as well the GI hormone gastric inhibitory peptide (GIP)), is in the final stretch of FDA-approval of its active ingredient, tirzepatide, as a weight management medication as well

Always speak with a licensed healthcare provider before starting, stopping, or changing any medication or weight-loss plan

SUSTAIN-6 (cardiovascular outcomes in T2D, Marso et al., NEJM 2016) reported a 26% reduction in MACE versus placebo over 104 weeks, the original cardiovascular signal that established the GLP-1 class's broader metabolic-protection profile beyond glycaemic control