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Clinical Scenarios of Interest To address further practical considerations, four clinical scenarios are described that are aimed at providing clues for the better management of GI AEs in those patients at higher risk of these complications that are going to undergo GLP-1 RA-based therapy (Table 4)

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The body of evidence across multiple studies in various countries is conclusive that treatment with GLP-1 medications for type 2 diabetes and/or overweight/obesity is strongly associated with an elevated risk of developing NAION