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GLP-1 Clinical Guidance vs Patient Behavior | Omada Health By Justin Wu, MD and Liz Connolley This edition covers: The phenomenon of GLP-1 discontinuation Clinical guidelines versus patient behavior How Omada members view the role of GLP-1s In my tenure as a physician, I have never seen another drug come close to the all-encompassing fervor surrounding GLP-1 medicationsfrom their impressive outcomes to a myriad of financial, social, and clinical challenges

Ramracheya R, Ward C, Shigeto M et al (2010) Membrane potential-dependent inactivation of voltage-gated ion channels in alpha-cells inhibits glucagon secretion from human islets

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In the retatrutide trials, the ratio of fat loss to lean loss was favorable compared to caloric restriction alone, where lean mass can represent 25-35% of total weight lost

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