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Further, the CV benefit of GLP-1 RAs, SGLT2 inhibitors and pioglitazone is independent of their glucose lowering effect and occurs on top of optimal treatment of traditional CV risk factors

What clinical evidence supports using GLP-1 agonists with metformin

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The two medications work through entirely different mechanisms, meaning they do not directly compete for the same biological targets

Hence, there is a need for treatment strategies for reducing body weight, in addition to improving glycaemic control, in patients with T2D